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Testing & Services

In-vivo Testing

APS offers an array of in-vivo testing. We have both large and small animal capabilities with numerous study designs that can be used for biocompatibility evaluations. Let our experienced staff help you select or design the right in-vivo tests to meet all of your requirements.

Sensitization Testing

  • Guinea Pig Maximization
  • Buehler
  • Murine Local Lymph Node Assay (LLNA)

Irritation Testing

  • Intracutaneous Reactivity 
  • Vaginal Mucosal Irritation
  • Systemic Toxicity Testing
  • Materials Mediated Pyrogenicity
  • Acute Systemic Toxicity
  • Sub-acute Toxicity
  • Sub-chronic Toxicity
  • Chronic Toxicity

Implantation Testing

  • Subcutaneous Implant
  • Intramuscular Implant

In-Vivo Thrombogenicity Testing

  • Canine, Porcine, Ovine, Bovine
  • 4hr, 72hrs
  • Standard and Custom Designs

Not all in-vivo thrombogenicity studies are created equal.

As the designs of medical devices continue to become more advanced, the overall placement of the device challenges traditional methods. Currently, devices subject to a standard thrombogenicity test are typically placed into the jugular vein with minimal concern as to the impact of blood flow, fit or placement. In reality the traditional design lacks the ability to ensure a proper placement of a device and it is not possible to confirm that proper blood flow has been maintained prior to starting the four-hour indwelling period.

The in-vivo thrombogenicity studies are especially challenging tests for many labs to conduct, given the required equipment, in-house technical expertise and implantation methodologies needed. APS offers you these services, plus superior surgical and interventional deployment techniques using fluoroscopy, which makes the test more reliable and reproducible.

Take a look inside at the capabilities that APS has to offer...

American Preclinical Services (APS) is a State of the Art, ISO 17025 accredited, AAALAC accredited, USDA registered and GLP compliant Contract Research Organization (CRO) located in Minneapolis, MN.

We are a comprehensive CRO whose catalogue includes ISO10993, USP, USP, JMHLW, custom biocompatibility testing, interventional, surgical, toxicology, pharmacology, pain, cadaver and bioskills, model development and complete pathology services.

Whether your company is a startup or an established industry leader, APS’ experienced staff is uniquely qualified to tackle your project and meet your in-vivo and in-vitro preclinical research needs in a timely fashion. more