In-vivo Testing

APS offers an array of in-vivo testing. We work with both large and small animals, and numerous study designs that can be used for biocompatibility evaluations. Let our experienced staff help you select or design the right in-vivo tests to meet all of your device requirements.

Biocompatibility Catalog

Implantation Testing

Subcutaneous Implant
Intramuscular Implant
Bone Implant

In-Vivo Thrombogenicity Testing

Canine, Porcine, Ovine, Bovine
Standard and Custom Designs

Irritation Testing

Intracutaneous Reactivity
Animal Irritation Test
Vaginal Mucosal Irritation
Buccal Mucosal Irritation
Occular Irritation

Sensitization Testing

Guinea Pig Maximization
Buehler

Systemic Toxicity Testing (IV, IP, Implant)

Materials Mediated Pyrogenicity
Acute Systemic Toxicity
Sub-acute Toxicity
Sub-chronic Toxicity
Chronic Toxicity

Genotoxicity

In-Vivo Mouse Micronucleus Assay

Why APS Should be Your Biocompatibility Testing Partner

American Preclinical Services offers a full biocompatibility testing program. We pride ourselves on being overly communicative and take the time to understand the specifics of your medical devices, allowing us to take a clinically relevant approach to designing and implementing your panel of biocompatibility assays. At APS you benefit from:

A team of professionals that understand the clinically indicated use of medical devices and assist in defining the appropriate biocompatibility testing required for your device and developing any necessary custom techniques to allow for reliable testing of even the more complex medical devices.
A variety of custom extractions to meet your device needs.
A focus on minimizing the number of devices used through test planning and extractions.
Biocompatibility testing according to ISO, USP, and JMHLW guidelines.
USDA-registered facilities that are accredited by ISO 17025 and the American Association for the Accreditation of Laboratory Animal Care (AAALAC).