Testing & Services

Testing & Services

APS does
what others can't!

See what makes us different

Pain Models

 At APS, we rigorously characterize and validate our models so that you can make informed decisions about study design and collect the most reliable data possible.  Through our validation process, we understand the time course and magnitude of each pain-related behavior and we use clinically-relevant analgesics to characterize the sensitivity of each endpoint in each model.  Our highly trained staff are capable of dosing via standard and specialized routes (including spinal delivery).

Neuropathic Pain

  • SNL - Spinal Nerve Ligation
  • CCI - Chronic Constriction Injury
  • LPA - Lysophosphatidic Acid
  • Fibromyalgia

Bone and Joint Pain

  • MIA-OA - Monosodium Iodoacetate - Induced Osteoarthritis
  • CFA-Arthritis - Complete Freund's Adjuvant Arthritis
  • MRMT induced bone cancer pain

Inflammation and Inflammatory Pain

  • CFA - Complete Freund's Adjuvant
  • UVB - Ultraviolet B Irradiation induced inflamation
  • Carrageenan
  • Formalin

Post Surgical Pain

  • Plantar

Acute and Chemogenic Pain

  • Hot Plate
  • Tail Flick
  • Capsaicin
  • Acetic Acid Writhing

Adverse Event Profiling

  • Rotorod
  • GIT - Gastrointestinal Transit
  • FOB - Functional Observational Battery

Visceral Pain

  • Colorectal Distention
  • Urinary Bladder Sensitivity


To download a copy of the APS Pain Model Catalog fill out the information below.


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Take a look inside at the capabilities that APS has to offer...

American Preclinical Services (APS) is a State of the Art, ISO 17025 accredited, AAALAC accredited, USDA registered and GLP compliant Contract Research Organization (CRO) located in Minneapolis, MN.

We are a comprehensive CRO whose catalogue includes ISO10993, USP, USP, JMHLW, custom biocompatibility testing, interventional, surgical, toxicology, pharmacology, pain, cadaver and bioskills, model development and complete pathology services.

Whether your company is a startup or an established industry leader, APS’ experienced staff is uniquely qualified to tackle your project and meet your in-vivo and in-vitro preclinical research needs in a timely fashion. more