Testing & Services

Testing & Services

Pathology Services

Pathology is the gold standard for the evaluation of medical device performance and safety designed for high volume and rapid throughput to meet and exceed all of your tissue and device collection requirements. APS has extensive histopathology services for preclinical research studies. We also offer a full set of services for studies performed at outside labs, as well as pathologist consulting services conducted within a comfortable working environment.

The APS pathology department operates a fully equipped, 5,000 square foot, histopathology and SEM laboratory in the main facility. APS pathology lab is operated by board certified histotechnicians and has advanced equipment for the precise sectioning of all medical devices, using paraffin, plastic thin microtomy, plastic EXAKT ground sectioning, and SEM techniques. 

Our dedicated necropsy labs feature down draft tables, as well as gravity and static pressure perfusion systems to ensure that, once harvested, organs are completely fixed prior to histoprocessing.  APS pathology staff are also highly skilled at intricate dissections necessary for today's complex tissue treatments and device implants. We take tissue and device harvest seriously.  

APS has both board certified veterinary pathologists and MD, PhD pathologists who oversee gross necropsies, interpret histopathology slides and write reports evaluating the safety of products. Our pathology services technicians possess college degrees, histotechnology board certifications and have many years of hands-on experience.


Gross Pathology Capabilities

Post-mortem Exams

  • Large / Small Animal
  • Microdissection
  • In-situ perfusion fixation
  • Ex-vivo perfusion fixation
  • Fluorogram guided tissue harvesting
  • Pharmacokinetic sampling
  • TTC in-situ and ex-vivo staining
  • Evans blue staining


  • Stereomicroscopy
  • High Resolution radiography (Faxitron)
  • OCT
  • IVUS
  • Fluoroscopy
  • Scanning Electron Microscope
  • Histomorphometry


Histopathology Capabilities

Embedding Capabilities:

  • Paraffin embedding
  • OCT medium
  • Spurr's Resin
  • MMA

Sectioning Techniques:

  • Microtomy
  • Cryosectioning
  • Plastic microtomy and EXAKT grinding
  • EXAKT grinding

Specialty Capabilities:

  • TTC in-situ staining
  • TTC ex-vivo staining
  • Resin and silicone Castings
  • Evan's Blue

Histology Stains:

  • Hemotoxylin and Eosin
  • Verhoeff Van Gieson
  • Luxol Fast Blue
  • PTAH and Carstairs (fibrin or muscle striations)
  • Gram
  • Von Kossa
  • Masson's Trichrome
  • Gomori Trichrome
  • Masson's Elastic Trichrome
  • Gomori Elastic Trichrome
  • Goldner's Trichrome
  • Movat's Pentachrome 

Take a look inside at the capabilities that APS has to offer...

American Preclinical Services (APS) is a State of the Art, ISO 17025 accredited, AAALAC accredited, USDA registered and GLP compliant Contract Research Organization (CRO) located in Minneapolis, MN.

We are a comprehensive CRO whose catalogue includes ISO10993, USP, USP, JMHLW, custom biocompatibility testing, interventional, surgical, toxicology, pharmacology, pain, cadaver and bioskills, model development and complete pathology services.

Whether your company is a startup or an established industry leader, APS’ experienced staff is uniquely qualified to tackle your project and meet your in-vivo and in-vitro preclinical research needs in a timely fashion. more